§ 139 When the physician does not make the trial of the medicine on himself, but gives it to another person, the latter must note down distinctly the sensations, sufferings, accidents and changes of health he experiences at the time of their occurrence, mentioning the time after the ingestion of the drug when each symptom…

§ 138 All the sufferings, accidents and changes of the health of the experimenter during the action of a medicine (provided the above condition [§§ 124-127] essential to a good and pure experiment are complied with) are solely derived from this medicine, and must be regarded and registered as belonging peculiarly to this medicine, as…

§ 137 The more moderate, within certain limits, the doses of the medicine used for such experiments are – provided we endeavor to facilitate the observation by the selection of a person who is a lover of truth, temperate in all respects, of delicate feelings, and who can direct the most minute attention to his…

§ 136 Although, as has been said, a medicine, on being proved on healthy subjects, cannot develop in one person all the alterations of health it is capable of causing, but can only do this when given to many different individuals, varying in their corporeal and mental constitution, yet the tendency to excite all these…

§ 135 The whole of the elements of disease a medicine is capable of producing can only be brought to anything like completeness by numerous observations on suitable persons of both sexes and of various constitutions. We can only be assured that a medicine has been thoroughly proved in regard to the morbid states it…

Aphorism 134 § 134 Aphorism 134 : All external influences, and more especially medicines, possess the property of producing in the health of the living organism a particular kind of alteration peculiar to themselves; but all the symptoms peculiar to a medicine do not appear in one person, nor all at once, nor in the…

Aphorism 133 § 133 Aphorism 133 : On experiencing any particular sensation from the medicine, it is useful, indeed necessary, in order to determine the exact character of the symptom, to assume various positions while it lasts, and to observe whether, by moving the part affected, by walking in the room or the open air,…

Aphorism 132 § 132 Aphorism 132 : But when the object is, without reference to the sequential order of the phenomena and the duration of the action of the drug, only to ascertain the symptoms themselves, especially those of a weak medicinal substance, in that case the preferable course to pursue is to give it…

Aphorism 131 § 131 Aphorism 131 : If, however, in order to ascertain anything at all, the same medicine must be given to the same person to test for several successive days in ever increasing doses, we thereby learn, no doubt, the various morbid states this medicine is capable of producing in a general manner,…

Aphorism 130 § 130 Aphorism 130 : If, at the very commencement, the first dose administered shall have been sufficiently strong, this advantage is gained, that the experimenter learns the order of succession of the symptoms and can note down accurately the period at which each occurs, which is very useful in leading to a…