Nephrotic syndrome

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Nephrotic syndrome

Definition

Nephrotic syndrome is a clinical condition in which there is oedema, proteinuria and hypoproteinaemia and hyperlipidaemia irrespective of aetiology. Or any other additional abnormal clinical features [1] 

Nephrotic syndrome itself doesn’t have true synonyms because it’s a specific diagnosis. However, there are several ways to describe it depending on the context and desired level of detail.

For broader understanding:

You could use terms like "proteinuric kidney disease" or "glomerular disease with proteinuria." These terms highlight the key features of nephrotic syndrome: protein leakage in the urine (proteinuria) and damage to the glomeruli, the tiny filtering units within the kidneys.

Focusing on cause:

If you know the underlying cause of the nephrotic syndrome, you can use a more specific term. Here are some examples:

  • Minimal change disease: This is the most common cause in children and is characterized by normal-looking glomeruli under a microscope despite causing significant proteinuria.
  • Focal segmental glomerulosclerosis (FSGS): This is another cause affecting both children and adults, where scarring damages specific parts of the glomeruli.
  • Membranous nephropathy: This is a cause more common in adults, where abnormal deposits form on the glomerular membrane, hindering its filtering function.

Hereditary forms:

For specific genetic types, you can use "hereditary nephrotic syndrome." This term indicates a familial predisposition to the condition.

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